Features of threatening cues and the associated context influence the perceived imminence of threat and the defensive responses evoked. To provide additional knowledge about how the directionality of a threat (i.e. directed-towards or away from the viewer) might impact defensive responses in humans, participants were shown pictures of a man carrying a gun (threat) or nonlethal object (neutral) directed-away from or towards the participant. Cardiac and electrodermal responses were collected. Compared to neutral images, threatening images depicting a gun directed-towards the (...) participant induced sustained bradycardia and an increased electrodermal response, interpreted as immobility under attack. This defensive immobility reaction is evoked by high perceived threat and inescapable situations and indicates intense action preparation. Pictures of guns directed-away from the participant induced shorter bradycardia and no significant modulation of the electrodermal response compared to neutral pictures, which might be consistent with the perception of a less threatening situation. The results show that the directionality of threat stimuli is a key factor that prompts different patterns of defensive responses. (shrink)

Cultural routines, such as reading and writing direction (script direction), channel attention orientation. Depending on one's native language habit, attention is biased from left‐to‐right (LR) or from right‐to‐left (RL). Here, we further document this bias, as it interacts with the spatial directionality that grounds time concepts. We used a spatial cueing task to test whether script direction and the grounding of time in Portuguese (LR, Exp. 1) and Arabic (RL, Exp. 2) shape visuomotor performance in target discrimination. Temporal words (e.g., (...) tomorrow, yesterday) were presented as cues in two modalities: visual (Exp. 1–2) and auditory (Exp. 1). Gaze movement (Exp. 1) and speed of discrimination decisions (Exp. 1–2) of targets presented to the left or right sides of the screen were assessed. As predicted, the interaction between target location and time concepts was significant across both modalities and linguistic communities. Additionally, LR participants detected the target on the right side of the screen faster after a future word than the target on the left side of the screen after a past word cue. In contrast, RL participants detected the target on the left side of the screen faster when the cue word was a future word than the target on the right side of the screen cued by a past word. In both modalities, the initial eye‐gaze movement (Exp. 1) was responsive to the cue's time referent, further confirming that time orients attention. An additional bias was observed for the first fixation onset, which landed earlier on the target set that matched habitualized spatial routines. We conclude that scanning regularities are shaped by writing habits and bodily grounded categorical features. (shrink)

This review is focused on recent advances in our understanding of the development of coordinated cell polarity, through experiments on the Drosophila compound eye. Each eye facet (or “ommatidium”) contains a set of eight photoreceptor cells, placed so that their rhabdomeres form an asymmetric trapezoid. The array of ommatidia is organized so that these trapezoids are aligned in two mirror-image fields, dorsal and ventral to the eye midline (or “equator”). The development of this pattern depends on two systems of positional (...) information that inform the cluster of cells that will form an ommatidium of anterior/posterior (a/p) and dorsal/ventral (d/v) direction. The former (a/p) is encoded by a progressive wave of development (the morphogenetic furrow). The latter (d/v) involves molecules known to act in tissue polarity in other organs and organisms. Our understanding of the function of these molecules rests not only on their mutant phenotypes, biochemistry, and expression patterns, but also on the spatial effects when mutant patches of cells are made (genetic mosaics). BioEssays 21:275–285, 1999. © 1999 John Wiley & Sons, Inc. (shrink)

El uso de las Tecnologías de la información y la comunicación ha permitido introducir mejoras en la forma como se desarrollan los procesos de enseñanza y aprendizaje, así como los procesos propios a la gestión y administración de las actividades académicas. Sin embargo, el índice de adopción de estas herramientas es reducido en cobertura y en profundidad. No obstante, para el uso de la herramienta Teams hay que detallar las ventajas y desventajas encontradas y finalizar con conclusiones en base a (...) las experiencias personales. Palabras Clave: software, Microsoft Teams, herramienta, ventajas, experiencia. Referencias [1]C. E. F. Pabón, «MÁS ALLÁ DE ZOOM, GOOGLE MEET, TEAMS…,» Slidesgo, vol. 1, nº 1, p. 12, 2020. [2]F. García, A. Correl, V. Abella y M. Grande, «La evaluación online en la educación superior en tiempos de la COVID-19,» EDUCATION IN THE KNOWLEDGE SOCIETY, vol. 21, nº 1, pp. 1-12, 2020. [3]G. Jose, C. Alfredo, G. Victor y GrandeMario, «Education in the Knowledge Society,» Ediciones Universal Salamanca, vol. 1, nº 12, p. 26, 14 05 2020. [4]E. Dans, «Educacion online: Plataformas educativas y el dilema de la apertura,» Universidad y Sociedad del Conocimiento, vol. 6, nº 1, p. 10, 02 03 2009. [5]A. Mauricio, A. Roberto, V. Edgar y F. Karen, «Convergencia de procesos de docencia universitaria: El uso de la aplicacion Teams de Microsoft,» ResearchGate, vol. 1, nº 1, p. 9, 21 11 2019. [6]B. Jose, L. Lina, H. Maria y J. Eusebio, «Utilización del alfa de Cronbach para validar la confiabilidad,» Engineering and Technology, vol. 11, nº 1, p. 9, 16 08 2013. [7]J.-J. a. C.-R. D. a. D. P. Monedero-Moya, «Usabilidad y satisfacción en herramientas de anotaciones multimedia para MOOC = Usability and Satisfaction in Multimedia Annotation Tools for MOOCs,» e-Lis, vol. 22, nº 44, p. 62, 2018. [8]I. Ros Martínez de Lahidalga, «Moodle, la plataforma para la enseñanza y organización escolar,» Ikastorratza, e- Revista de Didáctica, vol. 2, nº 50, p. 12, 2008. [9]D. Marlene, «Herramientas para la producción de materiales didácticos para las modalidades de enseñanza semipresencial y a distancia,» ACIMED, vol. 16, nº 2, p. 5, 2007. [10]C. Barbara, «Diseño y validación de un instrumento,» Universitat Illes Balears, vol. 4, nº 50, p. 415, 10 2006. (shrink)

Emotional, social, and cognitive intelligence competencies have been recognized as the most critical capabilities for organizations to acquire at all levels. For this reason, a wide body of research since the 1980s has demonstrated their positive impact on individual performance, career success, and wellbeing across sectors and professional roles, and a large number of theoretical contributions on how these competencies can be effectively developed has emerged over time. We focus attention on the developmental and learning processes of emotional, social, and (...) cognitive intelligence competencies that occur after formal training or educational courses provided by universities or certified organizations and directed to students or practitioners. Specifically, we conduct an exploratory literature review on the existing academic studies in order to identify the scholars and the pieces of research contributing most to the debate under investigation. This article aims at analyzing this body of research through a systematic review of the literature in order to: i) provide a comprehensive critical analysis of the distinctive features of the theoretical and methodological frameworks adopted to develop these competencies; ii) review the contexts in which the training initiatives analyzed by the literature have been delivered and the categories of learner involved; iii) discuss the learning outcomes of these educational programs and how they have been assessed; iv) identify gaps and inconsistencies in the current state of the literature, suggesting promising paths for future research; and v) stimulate insights for educators, human resource managers, executives, and policymakers by organizing and critically analyzing the extant contributions on competency development. This review represents the first attempt to systematize the methodologies of the educational programs for competency development and to assess their effectiveness in order to assist educators and executives in their ongoing efforts to equip students and employees with the relevant skills needed to achieve superior performance in the workplace. At the institutional level, policymakers should promote a dedicated agenda with concrete actions to equip people with emotional and social intelligence competencies. (shrink)

Rita Bottino,1 Santosh Nagaraju,2 Vikas Satyananda,2 Hidetaka Hara,2 Martin Wijkstrom,2 Massimo Trucco,1 David KC Cooper2 1Institute of Cellular Therapeutics, Allegheny Health Network, 2Thomas E Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA: Diabetes mellitus is increasing worldwide. Type 1 diabetes can be treated successfully by islet allotransplantation, the results of which are steadily improving. However, the number of islets that can be obtained from deceased human donors will never be sufficient to cure more than a (...) very small percentage of patients who might benefit from transplantation. Although there are some differences in glucose metabolism between pigs and humans, the use of pigs could provide an unlimited supply of islets, and the insulin produced would undoubtedly control glucose levels. Transplantation of islets into the portal vein results in islets residing in the liver; however, an early inflammatory response and rejection remain problematic, even when the recipient is receiving immunosuppressive therapy. In the long term, immunosuppressive drugs may exhibit toxicities to patients and specifically harm the islet cells. In contrast, encapsulation techniques provide islets with a physical barrier that prevents antibodies binding to the islet graft while still allowing insulin to be released into the recipient's circulation; in theory, patients receiving encapsulated grafts might not require exogenous immunosuppressive therapy. Nonhuman primates with encapsulated pig islet transplants have remained insulin-independent for several weeks, but long-term efficacy remains uncertain. Furthermore, techniques are now available to knock out genes from the pig and/or insert human genes, thus rendering the antigenic structure of pigs closer to that of humans, and providing protection from the human immune response. Islet transplantation from genetically engineered pigs has been followed by insulin independence in a small number of nonhuman primates for greater than 1 year. Neonatal islets have some advantages over adult islets in that they are easier to isolate and culture, and have the ability to proliferate during the first few months after transplantation. In 2009, the International Xenotransplantation Association set up a group to encourage and advise on clinical trials of pig islet xenotransplantation; this group's guidelines are discussed. Clinical trials of encapsulated pig islets are already under way. Keywords: diabetes, islets, pancreatic, pig, xenotransplantation. (shrink)

Previous research suggests that how people conceive of minds depends on the culture in which they live, both in determining how they interact with other human minds and how they infer the unseen minds of gods. We use exploratory factor analysis to compare how people from different societies with distinct models of human minds and different religious traditions perceive the minds of humans and gods. In two North American samples (American adults, N = 186; Canadian students, N = 202), we (...) replicated a previously found two‐factor agency/experience structure for both human and divine minds, but in Fijian samples (Indigenous iTaukei Fijians, N = 77; Fijians of Indian descent, N = 214; total N = 679) we found a three‐factor structure, with the additional containing items related to social relationships. Further, Fijians’ responses revealed a different three‐factor structure for human minds and gods’ minds. We used these factors as dimensions in the conception of minds to predict (a) expectations about human and divine tendencies towards punishment and reward; and (b) conception of gods as more embodied (an extension of experience) or more able to know people's thoughts (an extension of agency). We found variation in how these factors predict conceptions of agents across groups, indicating further theory is needed to explain how culturally generated concepts of mind lead to other sorts of social inferences. We conclude that mind perception is shaped by culturally defined social expectations and recommend further work in different cultural contexts to examine the interplay between culture and social cognition. (shrink)

Монография предназначена для специалистов в области социальной философии, социологии и истории, а также для широкого круга читателей.

для научных работников, преподавателей, аспирантов, студентов юридических вузов и факультетов.

t. 1. Vlastʹ kli︠u︡cheĭ -- t. 2. Na vesakh Iova.

This text consists of two parts. The first part is an interview given by Aleksandr Moiseevich Piatigorskii to Vadim Nikolaevich Sadovskii. Both are graduates of the Department of Philosophy at Moscow State University in the first postwar years. Meeting in London in 1992, they decided to discuss how they studied philosophy at that time. As time was short, for all practical purposes only Piatigorskii's reflections were recorded on tape. Hence, on the suggestion of the editorial board, a second part, containing (...) Sadovskii's account of these same topics, was produced—written in Moscow, of course. (shrink)

© 2015 Elsevier Inc.Postnatal organogenesis occurs in an immune competent environment and is tightly controlled by interplay between positive and negative regulators. Innate immune cells have beneficial roles in postnatal tissue remodeling, but roles for the adaptive immune system are currently unexplored. Here we show that adaptive immune responses participate in the normal postnatal development of a non-lymphoid epithelial tissue. Since the mammary gland is the only organ developing predominantly after birth, we utilized it as a powerful system to study (...) adaptive immune regulation of organogenesis. We found that antigen-mediated interactions between mammary antigen-presenting cells and interferon-γ -producing CD4+ T helper 1 cells participate in MG postnatal organogenesis as negative regulators, locally orchestrating epithelial rearrangement. IFNγ then affects luminal lineage differentiation. This function of adaptive immune responses, regulating normal development, changes the paradigm for studying players of postnatal organogenesis and provides insights into immune surveillance and cancer transformation. Plaks et al. (shrink)